A panoramic review on ethnomedicinal, therapeutic, phytochemical, and advance attributes, of the genus Ziziphus Mill., native to Pakistan

Background: Medicinal plants have gained prime importance in treating several fatal diseases, such as cancer, diabetes, and eczema, because they are a rich source of bioactive phytochemicals safer alternative to synthesized chemical compounds. Genus Ziziphus Mill. belongs the family Rhamnaceae, which comprises 100 accepted plant species is well known for multipurpose applications food, fodder, fuels, medicine, timber, alcohol, cosmetics, poison, etc. Six genus indigenous Pakistan, famous nummularia (Burm.f.) Wight & Arn., mauritiana Lam., jujuba Mill., spina-christi (L.) Desf., rugosa oxyphylla Edgew. Method: Several search engines online databases, including Sci-hub, PubMed, Google Scholar, Flora research gate, Science Direct, were used perform an exhaustive literature survey this review. Both original studies relevant review articles done till 2022 included. Result: These been traditional Ayurveda medicine treat diseases like fever, skin infections, urinary problems, Numerous components found, alkaloids, flavonoids, phenols, terpenoids, organic acids, exhibit variety biological properties, anticancer, antimicrobial, anti-hair fall, antinociceptive, antipyretic, larvicidal, anti-diabetic actions. Conclusion: This demonstrates phytochemical composition, uses, pharmacological nanoparticle-based activity lays down scientific foundation further investigation on usage Ziziphus. Moreover, indicates that jujube has hair growth effect its high nutritional value activities. Keywords: Cancer; Ethnobotany; Nanoparticles; Pharmacology; Phytochemical;